METHOD OF EVALUATING THE EFFICACY OF DRUG ON BRAIN NERVE CELLS

摘要

The present invention relates to a method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of: a) measuring NAA signal intensity using MRS of the brain of the patient; b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain; whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.