ATTENUATED POLIOVIRUSES

摘要

An attenuated poliovirus, suitable for vaccination against poliomyelitis, does not have a U-G base pair or other base pair mismatch in stem (a) or (b) of domain V of the 5' non-coding region of the poliovirus genome. The attenuated poliovirus may be a type 3 poliovirus whose 5' non-coding region contains the following U-A base pairs: (a) U-A at positions 472-537, U-A at positions 478-533 and U-A at positions 480-531; (b) U-A at positions 472-537, U-A at positions 480-531 and U-A at positions 481-530; or (c) U-A at positions 472-537, U-A at positions 480-531 and A-U at positions 482-529.