发明名称 Verbessertes Verfahren zur Herstellung von Thiazolidindionen
摘要 The invention relates to an improved method for producing compounds of the formula (III) wherein A represents CH=CH or S, W represents O, X represents S, O or NR<2>, the radical R<2> being hydrogen or C1-C6alkyl, Y represents CH or N, R represents naphthyl, thienyl or phenyl which is optionally mono- or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R<1> represents hydrogen or C1-C6 alkyl and n represents 1-3 by reacting compounds of the formula (IV) wherein A, W, X, Y, R, R<1> and n have the meaning given above with activated aluminum in a protic solvent. The invention also relates to new compounds of the formula III and medicaments containing these compounds.
申请公布号 DE19711616(A1) 申请公布日期 1998.09.24
申请号 DE19971011616 申请日期 1997.03.20
申请人 BOEHRINGER MANNHEIM GMBH, 68305 MANNHEIM, DE 发明人 WOLFF, HANS-PETER, DIPL.-CHEM. DR., 69469 WEINHEIM, DE;WITTE, ERNST-CHRISTIAN, DIPL.-CHEM. DR., 68165 MANNHEIM, DE;KUEHNLE, HANS-FRIEDER, DIPL.-CHEM. DR., 69469 WEINHEIM, DE
分类号 A61K31/427;A61P3/10;C07D263/00;C07D277/00;C07D333/00;C07D417/12;C07D417/14;(IPC1-7):C07D417/14;A61K31/425;C07B35/02 主分类号 A61K31/427
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