发明名称 |
Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
摘要 |
The invention relates to an improved method for producing compounds of the formula (III) wherein A represents CH=CH or S, W represents O, X represents S, O or NR<2>, the radical R<2> being hydrogen or C1-C6alkyl, Y represents CH or N, R represents naphthyl, thienyl or phenyl which is optionally mono- or disubstituted with C1-C3 alkyl, CF3, C1-C3 alkoxy, F, Cl or bromine, R<1> represents hydrogen or C1-C6 alkyl and n represents 1-3 by reacting compounds of the formula (IV) wherein A, W, X, Y, R, R<1> and n have the meaning given above with activated aluminum in a protic solvent. The invention also relates to new compounds of the formula III and medicaments containing these compounds.
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申请公布号 |
DE19711616(A1) |
申请公布日期 |
1998.09.24 |
申请号 |
DE19971011616 |
申请日期 |
1997.03.20 |
申请人 |
BOEHRINGER MANNHEIM GMBH, 68305 MANNHEIM, DE |
发明人 |
WOLFF, HANS-PETER, DIPL.-CHEM. DR., 69469 WEINHEIM, DE;WITTE, ERNST-CHRISTIAN, DIPL.-CHEM. DR., 68165 MANNHEIM, DE;KUEHNLE, HANS-FRIEDER, DIPL.-CHEM. DR., 69469 WEINHEIM, DE |
分类号 |
A61K31/427;A61P3/10;C07D263/00;C07D277/00;C07D333/00;C07D417/12;C07D417/14;(IPC1-7):C07D417/14;A61K31/425;C07B35/02 |
主分类号 |
A61K31/427 |
代理机构 |
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