| 摘要 |
<p>The present invention provides for a method of injecting an antibiotic in the ear of an animal, such as cattle, swine, sheep and goats. These injectable antibiotics include the following: injectable suspensions of sparingly water-soluble antimicrobial agents, such as procaine penicillin, benzathine penicillin, ceftiofur crystalline free acid of formula (I), ceftiofur hydrochloride, ampicillin trihydrate and amoxicillin trihydrate; sustained-release non-aqueous solutions of sparingly water-soluble antimicrobial agents, such as oxytetracycline, erythromycin, tylosin, tilmicosin and florfenicol; and injectable solutions of zwitterionic antimicrobial agents, such as enrofloxycin, danofloxacin, premafloxacin, ceftiofur sodium, and lincomycin hydrochloride. Specifically, the present invention provides for a method of injecting a relatively large volume (1 to 15 mL) of a sterile oil suspension of an antibiotic, such as ceftiofur crystalline free acid, in the posterior of the ear of cattle and swine. The compound of formula (I) is also named 7-[2-(2-amino-1,3-thiazol-4-yl) -2-methoxyimino)acetamino]-3-[(fur-2-ylcarbonyl)thiomethyl] -3-cephem-4-carboxylic acid.</p> |
