Process of preparation of endo-tropine

摘要

Preparation of endo-tropine (I) (i.e. 3 alpha -tropanol) comprises catalytic reduction of tropanone (II) by hydrogenation over Raney nickel or Raney copper in aqueous solution with hydrogen at atmospheric pressure and room temperature in a closed system, with stirring at 1000-1500 rpm. Also claimed are: (i) use of a high speed stirring apparatus for carrying out the process; and (ii) (I) obtained by the process using a high speed stirring apparatus.