Derivatives of 7-deaza-2'-deoxy-guanosine-5'-triphosphate, preparation and use thereof

摘要

Molecule comprising the following moiety: wherein R 1 is C 1-10 alkyl group optionally substituted by hydroxyl, amino, C 1-4 alkoxy or halo; and R 2 is hydrogen or hydroxyl and R 7 is H or a mono-, di- or tri-phosphate or thiophosphate thereof. These compounds are used to prepare oligonucleotide sequences containing the 7-deaza species and are useful in biological processes such as resolution of compression artifacts in DNA sequencing.