Macromolecular contrast media for MR imaging

摘要

PCT No. PCT/US94/05597 Sec. 371 Date Jul. 28, 1995 Sec. 102(e) Date Jul. 28, 1995 PCT Filed May 19, 1994 PCT Pub. No. WO94/27498 PCT Pub. Date Dec. 8, 1994A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnetic complex. The polymeric backbone thus serves as an amplifier by supporting a multitude of paramagnetic complexes, and the spacer arms contribute to the molecular weight. The spacer arms further contribute useful properties to the agent, such as hydrophilicity and the ability to cleave at a relatively rapid rate in blood.