发明名称 |
Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
摘要 |
Adenovirus vectors replication specific for cells expressing alpha-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP. |
申请公布号 |
AU6679698(A) |
申请公布日期 |
1998.09.22 |
申请号 |
AU19980066796 |
申请日期 |
1998.03.03 |
申请人 |
CALYDON, INC. |
发明人 |
ANDREW S. LITTLE;HENRY G. LAMPARSKI;DANIEL R. HENDERSON;ERIC R. SCHUUR |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K47/48;A61K48/00;A61P35/00;C07K14/075;C07K14/47;C12N5/10;C12N7/00;C12N15/63;C12N15/861;C12Q1/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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