发明名称 Substituted 2,4-diaminopyrimidines
摘要 The invention is concerned with compounds of formula wherein R1 is lower-alkoxy, R2 is hydroxy or lower-alkoxy, R3 is hydrogen, cyano, alkyl, alkenyl, cycloalkyl, aryl, heterocycyl, aryl-Q-alkyl, or a group of the formula -CR4R4'COR5-, Q is -SO- or -SO2-; R4, R4' are each independently hydrogen, alkyl, aryl or heterocyclyl, R5 is hydrogen, alkyl, alkoxy, hydroxy, aryl or heterocycyl, or R4 and R5 together form -(CH2)n-, and n is a whole number between 2 to 5 inclusive and the enantiomers, epimers, and diastereomers thereof, as well as pharmaceutically acceptable salts thereof. These compounds have valuable antibacterial activity.
申请公布号 AU6823198(A) 申请公布日期 1998.09.22
申请号 AU19980068231 申请日期 1998.02.24
申请人 F.HOFFMANN-LA ROCHE AG 发明人 PHILIPPE GUERRY;CHRISTIAN HUBSCHWERLEN;SYNESE JOLIDON;JEAN-LUC SPECKLIN;PIERRE-CHARLES WYSS
分类号 A61K31/505;A61K31/506;A61K31/5377;A61P31/04;C07D401/14;C07D403/10;C07D403/14;C07D405/14;C07D409/14 主分类号 A61K31/505
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