发明名称 |
Vitamin-D amide derivatives |
摘要 |
PCT No. PCT/GB95/00658 Sec. 371 Date Nov. 20, 1996 Sec. 102(e) Date Nov. 20, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/25718 PCT Pub. Date Sep. 28, 1995The present invention relates to compounds of general formula (I) <IMAGE> (I) where R1 and R2, which may be the same or different, each represent a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic or aryl group or together with the nitrogen atom to which they are attached form a heterocyclic group; R3 represents a methyl group having alpha - or beta -configuration; one of Ra and Rb represents a hydroxy group or protected hydroxy group and the other represents a hydrogen atom; Y represents a valence bond or an alkylene group containing up to 3 carbon atoms; and A= represents a cyclohexylidene moiety characteristic of the A-ring of a 1 alpha -hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit separation of cell modulating and calcaemic activities coupled with enhanced duration of activity.
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申请公布号 |
US5811562(A) |
申请公布日期 |
1998.09.22 |
申请号 |
US19960704613 |
申请日期 |
1996.11.20 |
申请人 |
RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY INC. |
发明人 |
HESSE, ROBERT HENRY;SETTY, SUNDARA KATUGAM SRINIVASASETTY |
分类号 |
A61K31/59;A61P3/02;A61P7/02;A61P9/02;A61P11/00;A61P13/02;A61P15/00;A61P17/00;A61P19/10;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P37/00;A61P43/00;C07C401/00;(IPC1-7):C07C401/00;A01N45/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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