This invention provides an infectious retrovirus having inserted between the 5' and 3' long terminal repeat sequences of the retrovirus a nucleic acid encoding an anti-HIV-type specific agent under the control of a pol III promoter. Host cells containing the retroviral vectors of this invention also are provided. Further provided are methods of interfering with or preventing HIV viral replication in a cell infected with HIV or likely to be infected with HIV.
申请公布号
US5811275(A)
申请公布日期
1998.09.22
申请号
US19950465483
申请日期
1995.06.05
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
WONG-STAAL, FLOSSIE;YU, MANG;YAMADA, OSAMU;OJWANG, JOSHUA O.;LEAVITT, MARK;HO, ANTHONY