| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound useful as an intermediate for a substituted indrone derivative which is a medicine effective as a therapeutic agent for cardiovascular diseases and Parkinson's diseases. SOLUTION: This compound is represented by formula I [(n) is 2 or 3; R<2> is a 1-4C alkyl or a (substituted)phenyl; R<4> is CHO or CH=CHNO<2> ]. The compound of formula II (in formula I, R<4> is CHO) is obtained by reacting a compound of formula III in R<2> COCl, ZnCl2 or CH2 Cl2 at -10 to 0 deg.C, adding hexamethylenetetramine thereto, heating the mixture, extracting reaction mixture with CH2 Cl2 and repeating washing, etc., of the organic layer. The compound of formula IV (in formula I, R4 is CHNO2 ) is obtained by adding sodium methoxide/methanol solution and nitromethane at -10 to 0 deg.C to a compound of formula II and washing and drying the reaction mixture with an aqueous methanol. The compound is an intermediate especially useful for production of ropinirole.
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