发明名称 |
INDOLES |
摘要 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is a substituted alkylene; C3-C7 cycloalkyl optionally substituted with HO; C3-C6 alkenyl optionally substituted with aryl; C5-C7 cycloalkenyl; or C3-C6 alkynyl; R2 is H; halo; F3C; NC; R8R9NOC; a substituted alkylene; R8R9NO2S; R10S (O)m; R12CON(R11); R10SO2N(R11); R8R9NOCN(R11); R10O2CN(R11); R13(CH2)nCH=CH; or R7O are selective 5-HT 1-like re ceptor agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and heada che associated with vascular disorders.
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申请公布号 |
CA2131000(C) |
申请公布日期 |
1998.09.22 |
申请号 |
CA19932131000 |
申请日期 |
1993.03.25 |
申请人 |
PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. |
发明人 |
MACOR, JOHN EUGENE;WYTHES, MARTIN JAMES |
分类号 |
A61K31/40;A61K31/44;A61K31/4427;A61P3/04;A61P25/04;A61P25/20;A61P25/30;A61P43/00;C07D401/14;C07D403/06;(IPC1-7):C07D403/06;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;A61K31/495 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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