Method and probes for detecting nucleoside transporter and method for producing the probes

摘要

The present invention is directed to compounds capable of binding to the es nucleoside transporter of animal cells having the general formula: <IMAGE> <IMAGE> wherein n is 1-12; E is H, halogen, NH2, OH, OCH3, O(CH2)nCH3 (where n is 1 to 12), SH, SR (where R is CH3 or (CH2)nCH3 and n is 1 to 12); A is HN, S, O, Se; X is N or C; Y is N or C; Z is N or C; R1 is H or acyl; R2 is C1 to C20 substituted or unsubstituted alkyl or heteroalkyl; substituted or unsubstituted aliphatic carbocycle or heterocycle; substituted or unsubstituted arene or heteroarene, aryl or substituted aryl; heteroaryl or substituted heteroaryl; R3 is H, halogen, NO2, N3, SH, SR (where R is CH3 or (CH2)nCH3 and n is 1 to 12) when Y is C and R3 is absent when Y is N; R4 is H, OH [is] or halogen; R5 is H, OH, halogen, N3, acetal, hemiacetal; and R6 is H, [-C=O-HN2] -CO-NH2 or -C 3BOND N when X is C and R6 is [H] absent when X is N.