Methods for diagnosing and treating autoimmune disease

摘要

Methods and compositions for diagnosing autoimmune diseases are disclosed. The methods include determining the presence in a biological sample of the individual of an antibody specific for a phosphoprotein, an active protein kinase, or a protein complex containing a phosphoprotein or an active protein kinase which is present in a human apoptotic cell extract but which is not present in a human non-apoptotic cell extract. Also disclosed are methods of treating or preventing autoimmune diseases in an individual diagnosed in accordance with the aforementioned method.