Heterocyclic compounds as COX-2 inhibitors

摘要

The present invention relates to COX-2 inhibitors of the formula: <IMAGE> I wherein, A=halogen, C1-C6alkyl, SR1 or OR1; B=O, or H,H; X=Br or Cl; L=5-,6- or 7-membered heteroatom containing rings and is preferrably a 5-membered heteroaromatics such as thiazole, oxazole, imidazole, or oxadiazole; n=1-6, wherein the (C) is optionally branched; R=optionally substituted aryl wherein aryl is selected from phenyl, pyridyl, naphthyl, benzothienyl, or quinoxolyl, alkyl, carboxyl, esters, amino, amide, or urea; and R1=alkyl. The compounds are useful as research tools and could be useful as potential therapeutic agents in the inhibition of the PGHS-2 isozyme and in the treatment of inflammation in mammals including humans or other conditions associated with the production of prostaglandins.