| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new derivative, comprising a specific tetrazole derivative, having inhibiting actions on interleuklin-1βconverting enzymes and useful for prophylaxis and treatment, etc., of various inflammatory diseases such as autoimmune diseases, neurologic diseases, cancers or infectious diseases. SOLUTION: This new compound is represented by formula I R is H or a group, etc., represented by formula II (J is a single bond, a 1-6C alkylene, a 1-6C oxyalkylene, etc.; R<1> is a 1-8C alkyl, a 1-8C alkoxy, a 2-8C alkenyl, etc.); AA<1> is a single bond, a group, etc., represented by formula III (R<4> is H, a 1-8C alkyl, a carbocyclic ring, a heterocyclic ring, etc.); AA<2> is a single bond, a group, etc., represented by formula IV (R<9> and R<10> are each H, a 1-8C alkyl, a carbocyclic ring, a heterocyclic ring, etc.); Y is a group represented by formula V [R<19> is a group represented by the formula OR<30> (R<30> is a 9-20C alkyl, a 3-7C cycloalkyl, a heterocyclic ring, etc.); the formula NR<31> R<32> (R<31> and R<32> are each H, OH, a 1-8C alkyl, a 1-8C alkoxy, phenyl, etc.), etc.; (n) is 1-4; Z is a single bond, a 1-6C alkylene, O, S, CO, SO2 , etc.; formula VI is formula VII, etc.; E is H, a halogen, a 1-4C alkyl, phenyl, etc.]} and has inhibiting activities against IL-1βconverting enzymes.
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