PREVENTIVE AND THERAPEUTIC COMPOSITIONS FOR DRUG INDUCED NEPHROPATHY AND HEPATITIS

摘要

Novel agents for relieving drug-induced nephropathy and acute hepatitis, containing proteins belonging to the midkine (MK) family, e.g., pleiotrophin (PTN). The proteins belonging to the MK family can inhibit nephropathy induced by antineoplastic agents such as cisplatin or acute hepatitis due to carbon tetrachloride, thus being effective in relieving drug-induced nephropathy or hepatitis.