发明名称 |
PROCESS FOR THE PREPARATION OF 2-[[(2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLES AND NOVEL COMPOUNDS OF USE FOR SUCH PURPOSE |
摘要 |
2-[[(2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole derivatives of general formula (V) wherein R<2> represents H, OCH3, OCHF2 or CF3, R<3> represents H, CH3 or OCH3, R<4> represents H, OCH3, OCH2CF3, halo or nitro, R<5> represents H, CH3 or OCH3, and n is 0 or 1, or salts thereof, are prepared by a new process proceeding via novel intermediates of general formulae (I), (II), (III) and (Va) wherein R<1> represents branched or straight C1-8-alkyl, C3-8-cycloalkyl, aryl, aralkyl having 1-8 C-atoms in the alkyl moiety, or a 5- or 6-membered heterocyclic group having one, two or three hetero atoms selected from nitrogen, sulfur and oxygen in the heterocyclic ring. The compounds of formula (V) are biologically active and/or may be used as intermediates in the synthesis of biologically active compounds.
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申请公布号 |
WO9840378(A1) |
申请公布日期 |
1998.09.17 |
申请号 |
WO1998DK00059 |
申请日期 |
1998.02.16 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;CLAUSEN, FINN, PRIESS;MCCLUSKEY, KLAUS, KARL;PREIKSCHAT, HERBERT, FRITZ;PEDERSEN, SOEREN, BOLS |
发明人 |
CLAUSEN, FINN, PRIESS;MCCLUSKEY, KLAUS, KARL;PREIKSCHAT, HERBERT, FRITZ;PEDERSEN, SOEREN, BOLS |
分类号 |
C07D235/28;C07D401/12;C07D513/04;(IPC1-7):C07D401/12 |
主分类号 |
C07D235/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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