发明名称 |
NOVEL THIAZOLE DERIVATIVES AND THEIR PREPARATION |
摘要 |
1-(4-Bromomethyl-2-thiazolyl)guanidine, and its acid addition salts, especially 1-(4-bromomethyl-2-thiazolyl)guanidine hydrobromide are novel compounds useful as starting materials for the synthesis of famotidine. These compounds can be produced without need for prolonged reaction periods at extremely low temperatures by mixing 1,3-dibromoacetone and 2-imino-4-thiobiuret in a suitable reaction medium. Moreover, the novel compounds can be selectively synthesized in good yield and purity from a raw material containing a combination of structurally similar analogs of 1,3-dibromoacetone.
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申请公布号 |
WO9840367(A1) |
申请公布日期 |
1998.09.17 |
申请号 |
WO1998US04602 |
申请日期 |
1998.03.10 |
申请人 |
ALBEMARLE CORPORATION |
发明人 |
RAMACHANDRAN, VENKATARAMAN;MALCOLM, ARCELIO, J. |
分类号 |
C07D277/48;(IPC1-7):C07D277/48 |
主分类号 |
C07D277/48 |
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