发明名称 |
BICYCLIC COMPOUNDS, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION BASED THEREON |
摘要 |
<p>This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin having formula (I), their preparation, and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.</p> |
申请公布号 |
CZ9701899(A3) |
申请公布日期 |
1998.09.16 |
申请号 |
CZ19970001899 |
申请日期 |
1995.12.21 |
申请人 |
BIOCHEM PHARMA INC. |
发明人 |
DIMAIO JOHN;SIDDIQUI ARSHAD M.;GILLARD JOHN W.;ST-DENIS YVES;TARAZI MICHELINE;PREVILLE PATRICE;LEVESQUE SOPHIE;BACHAND BENOIT;EDMONDS JEREMY JOHN;DOHERTY ANNETTE MARIAN |
分类号 |
A61K;A61K31/435;A61K31/445;A61K31/47;A61K31/495;A61K31/54;A61K38/00;A61P7/02;A61P9/00;A61P9/08;A61P9/10;A61P11/00;C07D;C07D487/04;C07D513/04;C07K;C07K5/02;C07K5/065;C07K5/078;C07K5/087;C07K5/097;(IPC1-7):C07D513/04 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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