New thiazolo[5,4-d] thiazoles and processes for their manufacture

摘要

Compounds of the general formula (I) (wherein R and R1 each represents an amino group which may be mono- or di-substituted by lower hydrocarbon group(s) each of which lower hydrocarbon groups may be interrupted by an oxygen or sulphur atom or an imino group which may be substituted, and/or may be linked with the adjacent alkylene group and/or may be substituted, alk and alk1 each represents an alkylene group containing at least two carbon atoms and Ph and Ph1 each represents a phenylene group which is unsubstituted or is substituted by one or more substituents selected from lower alkyl groups, lower alkoxy groups, halogen atoms and trifluoromethyl groups) and their acid addition salts are prepared by (a)-when R and R1 are identical-reacting a compound of the Formula (II) (wherein Z and Z1 each represents a halogen atom) with RH, (b) reacting a compound of the Formula (III) with R1H, (c)-when R-alk and R1-alk1 are identical-reacting a compound of the Formula (IV) or a metal salt thereof, with R-alk-Y (wherein Y represents a halogen atom), or (d) reacting a compound of the Formula (V) or a metal salt thereof, with R1-alk1-Y, optionally followed in each case by salt formation. The " lower" groups contain up to nine carbon atoms. The preparation of starting materials of Formulae (II), (IV) and (V) and of 2-(p-hydroxyphenyl) - 5 - [p - (b - chloroethoxy)phenyl]-thiazolo-[5,4-d]thiazole is described. The compounds of the invention are useful in the treatment of tuberculosis, protozoal infections and arteriosclerosis, and may be administered in the form of pharmaceutical or veterinary preparations containing them, with or without other (unspecified) active ingredients, in association with a carrier.