PHARMACEUTICALLY ACTIVE COMPOUNDS BASED ON QUINOLINE

摘要

PCT No. PCT/GB96/02496 Sec. 371 Date Mar. 3, 1997 Sec. 102(e) Date Mar. 3, 1997 PCT Filed Oct. 14, 1996 PCT Pub. No. WO97/14686 PCT Pub. Date Apr. 24, 1997 (I) Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group -(CH2)cNHCO2R10, a group -(CH2)cNR5R6, or a group -CO2R11; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group -NHCO2R10; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)aZ(CH2)b; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.