| 发明名称 |
THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND THEIR DERIVATIVES WHICH INFLUENCE ENDOTHELIN ACTIVITY |
| 摘要 |
<p>Biphenylsufonamides of the following formula and methods for modulating or altering the activity of the endothelin family of peptides are provided. The sulfonamides may be used for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide <CHEM> or a pharmaceutically acceptable salt, acid or ester thereof, wherein Ar<2> is <CHEM> and wherein Ar<1>, R<13> and R<26> are as defined herein.m</p> |
| 申请公布号 |
CZ9703116(A3) |
申请公布日期 |
1998.09.16 |
| 申请号 |
CZ19970003116 |
申请日期 |
1996.04.04 |
| 申请人 |
TEXAS BIOTECHNOLOGY CORPORATION |
发明人 |
CHAN MING FAI;RAJU BORE GOWDA;KOIS ADAM;VERNER ERIK JOEL;WU CHENGDE;CASTILLO ROSARIO SIVESTRE;YALAMOORI VENKATACHALAPATHI;BALAJI VITUKUDI NARAYANAIYENGAR;KOGAN TIMOTHY |
| 分类号 |
C07D333/34;A61K31/38;A61K31/381;A61K31/42;A61K31/422;A61K31/427;A61K31/433;A61K31/4439;A61K31/496;A61P1/00;A61P1/04;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P13/02;A61P13/12;A61P15/00;A61P15/08;A61P17/00;A61P27/02;A61P27/06;A61P29/00;A61P43/00;C07D261/16;C07D413/12;C07D413/14;C07D417/12;C07D417/14;(IPC1-7):C07D261/16 |
主分类号 |
C07D333/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
