Secomacrolides and process for their preparation

摘要

The invention relates to novel secomacrolides from the class of erythromycin A, potential intermediates for preparation of novel macrolide antibiotics general formula (I), <CHEM> and its pharmaceuticaly acceptable addition salts with inorganic or organic acids, wherein R1 represents hydrogen, C1-C4 alkanoyl group, arylcarbonyl group and together with R2 and carbon atoms to which they are bound, cyclic carbonyl or thiocarbonyl group, R2 represents hydrogen or together with R1 and carbon atoms to which they are bound, cyclic carbonyl or thiocarbonyl group, R3 represents hydrogen, C1-C4 alkanoyl or arylcarbonyl group, Z is hydrogen or L-cladinosyl group represented by formula (i) <CHEM> wherein R4 represents hydrogen or C1-C4 alkanoyl group, W is hydrogen or D-desosaminyl group represented by formula (ii) <CHEM> wherein R5 represents hydrogen or C1-C4 alkanoyl or arylcarbonyl group, X and Y together represent a lactone, or X is CH2OR6,, wherein R6 represents hydrogen or C1-C4 alkanoyl group and Y is hydroxyl group.