摘要 |
There are described compounds of the formula: wherein R1 is alkyl, ar(lower)alkyl which may have suitable substituent(s), or heterocyclic(lower)alkyl, R2 is hydrogen or an acyl group, and R3 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxyaryl or protected carboxyaryl, and pharmaceutically acceptable salts thereof. These compounds can be used for treating and/or preventing thrombotic diseases such as transient cerebral ischemic attack, cerebral apoplexy, unstable angina, myocardial infarction, peripheral circulatory insufficiency, thrombus formation after percutaneous transluminal coronary angioplasty, disseminated intravascular coagulation syndrome or the like; allergic diseases such as asthma or the like; nephritis; peptic ulcer; hemicrania; diabetic neuropathy; diabetic angiopathy; restenosis after percutaneous transluminal coronary angioplasty; adult respiratory distress syndrome; shock; hepatitis; cerebral vasospasm after subarachnoidal hemorrhage; hypertension; arteriosclerosis; cancerous metastasis, thrombus formation on extracorporeal circulation; thrombus formation on transplantation; and the like and for reducing nephrotoxicity induced by immunosuppressants such as ciclosporin at renal transplantation, and can be also used with fibrinolytic agents in order to increase the effect of fibrinolytic agents; the preparation of these compounds and pharmaceutical compositions containing them.
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