| 摘要 |
There is provided an improved, fast-melting solid dosage form which readily disintegrates when placed in the mouth. The solid dosage form preferably being a tablet comprising the following primary ingredients whose proportions are calculated as weight percent on the total weight of the tablet: (a) from about 30 to 50 weight percent, of a pharmaceutically acceptable active ingredient component; (b) an effervescent couple consisting of about 3 to 5 weight percent of an effervescence base about 3 to 5 weight percent of an effervescence acid suitable for achieving a gas evolving reaction with the effervescence base upon being contacted with an aqueous solution such as saliva; (c) about 40 to 50 weight percent of a pharmaceutically acceptable starch as a bulking and disintegrating agent; (d) about 3 to 5 weight percent of a tablet lubricant. Additionally, the tablet may comprise flavoring agents. The tablet is formed of granules of a mixture of the active ingredient component, the effervescence base, and the starch, admixed to a powderous blend of the remaining ingredients, subsequently compressed in tablet form. Also provided is a method of making the solid dosage form of the present invention.
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