发明名称 |
Preparation of cis-4-O-protected-2-cyclopentenol derivatives |
摘要 |
The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and b) treating the solution with a suitable Lewis acid and a suitable reducing agent at a temperature of from about -100 DEG C. to about 20 DEG C. The cis-4-O-protected-substituted-2-cyclopentenol derivatives are useful intermediates in the preparation of various cyclopentanyl and cyclopentenyl purine analogs which are useful as immunosuppressants and in the preparation of various prostaglandins.
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申请公布号 |
US5808112(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19970877364 |
申请日期 |
1997.06.17 |
申请人 |
HOECHST MARION ROUSSEL INC. |
发明人 |
CURRAN, TIMOTHY T.;HAY, DAVID A.;EVANS, JONATHAN C. |
分类号 |
C07D333/32;C07B41/02;C07B53/00;C07C35/06;C07C41/26;C07C43/196;C07C309/66;C07D307/20;C07D309/12;C07F7/08;C07F7/18;C12P7/02;C12P41/00;(IPC1-7):C07D315/00 |
主分类号 |
C07D333/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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