发明名称 |
Catalytic antibodies for carbamate activation by a non-spontaneous reaction mechanism |
摘要 |
Catalytic antibodies capable of catalysing activation of a carbamate (-O-CO-NH-) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the prodrug at the carbamate position by a non-spontaneous reaction mechanism. The non-spontaneous reaction preferably has a BAc2 mechanism and the prodrug is a preferably a nitrogen mustard aryl carbamate. The invention also includes relevant immunogens, screens for catalytic activity using short transition state analogues and ADAPT systems.
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申请公布号 |
US5807688(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19960653060 |
申请日期 |
1996.05.24 |
申请人 |
ZENECA LIMITED |
发明人 |
BLACKBURN, GEORGE MICHAEL;WENTWORTH, PAUL |
分类号 |
A61K38/00;C07F9/44;C07F9/553;C12N9/00;C12N15/13;C12P21/08;(IPC1-7):C12N9/00;C12Q1/25 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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