发明名称 |
Non-steroid progesterone receptor agonist and antagonist and compounds and methods |
摘要 |
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
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申请公布号 |
US5808139(A) |
申请公布日期 |
1998.09.15 |
申请号 |
US19940303138 |
申请日期 |
1994.09.08 |
申请人 |
LIGAND PHARMACEUTICALS INCORPORATED;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PATHIRANA, I. CHARLES;BERGER, CHRISTINA S.;STEIN, ROBERT B.;FENICAL, WILLIAM;JONES, TODD K.;HAMANN, LAWRENCE G.;JOHNSON, MICHAEL G.;FARMER, LUC |
分类号 |
C07C69/96;(IPC1-7):C07C69/76 |
主分类号 |
C07C69/96 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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