发明名称 |
A METHOD OF EVALUATING THE EFFICACY OF DRUG ON BRAIN NERVE CELLS |
摘要 |
The present invention relates to a method to measure in vivo the effect of a drug on the function of the nerve cells of the brain of a patient suffering from a neurological disease, which comprises the steps of: a) measuring NAA signal intensity using MRS of the brain of the patient; b) subjecting the patient to a treatment with the drug to be tested and measuring NAA signal intensity using MRS of the brain of the patient; and c) comparing the spectra of steps a) and b) to determine whether the drug has an effect on the function of the nerve cells of the brain; whereby the increase in the NAA signal of step b) is indicative of a drug with a positive effect.
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申请公布号 |
CA2200045(A1) |
申请公布日期 |
1998.09.14 |
申请号 |
CA19972200045 |
申请日期 |
1997.03.14 |
申请人 |
ARNOLD, DOUGLAS L.;KALRA, SANGAY;CASHMAN, NEIL |
发明人 |
ARNOLD, DOUGLAS L.;KALRA, SANGAY;CASHMAN, NEIL |
分类号 |
G01R33/483;(IPC1-7):A61B5/055 |
主分类号 |
G01R33/483 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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