发明名称 |
PREPARATION OF PHOSPHONIUM COMPOUNDS AS INTERMEDIATES FOR GLYCINE ANTAGONISTS |
摘要 |
A process for the preparation of the phosphonium compound of formula (I), which comprises reacting N-phenylpyrrolidinone (II), with pyridinium bromide perbromide, in the presence of a tertiary organic base and a suitable lewis acid and then treating the resultant bromo derivative (III) with the phosphine (IV, R1R2R3P) and the use of compound (I) when so prepared for the preparation of the glycine antagonist.
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申请公布号 |
CA2282850(A1) |
申请公布日期 |
1998.09.11 |
申请号 |
CA19982282850 |
申请日期 |
1998.03.03 |
申请人 |
GLAXO WELLCOME SPA |
发明人 |
DOLAN, SIMON CHARLES;MARAGNI, PAOLO;PERBONI, ALCIDE |
分类号 |
C07D403/06;C07F9/572;(IPC1-7):C07F9/572;C07D207/26 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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