IMPROVED METHODS OF MAKING CROSS-BRIDGED MACROPOLYCYCLES

摘要

The present invention is directed to a method for preparing a complex o f manganese and a cross-bridged macropolycycle. The method comprises the steps of (A) forming a bisaminal from an acyclic amine; (B) forming a diquat derivative of said bisaminal; (C) reducing said diquat derivative; (D) separating reducing agent and solvent from the product step of (C) in one or more operations; (E) removing residual hydride from the product of (D); (F) isolating a cross - bridged tetraazamacrocycle product of steps (A)-(E); and (G) reacting the product of step (F) with a manganous containing compound, thereby forming a manganes e complex.