发明名称 |
PURIFIED AND RECOMBINANT ANTIGENIC PROTEINS ASSOCIATED WITH ABDOMINAL AORTIC ANEURYSM (AAA) DISEASE |
摘要 |
This invention provides an isolated protein of approximately 40 kDa which is purified from human aortic tissue and immunoreactive with AAA-associated immunoglobulin. Also provided are a method of diagnosing AAA disease in a subject using said isolated protein and a pharmaceutical composition comprising said isolated protein. A method of alleviating AAA disease in a subject comprising administering said pharmaceutical composition comprising the isolated protein is also provided. The subject invention also provides a recombinantly produced human aortic protein which is immunoreactive with AAA-associated immunoglobulin. Also provided are a method of diagnosing AAA disease in a subject using said recombinantly produced protein and a pharmaceutical composition comprising said recombinantly produced protein. A method of alleviating AAA disease in a subject comprising administering said pharmaceutical composition comprising the recombinantly produced protein is also provided.
|
申请公布号 |
WO9839356(A1) |
申请公布日期 |
1998.09.11 |
申请号 |
WO1998US04368 |
申请日期 |
1998.03.06 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;TILSON, MARTIN, DAVID |
发明人 |
TILSON, MARTIN, DAVID |
分类号 |
A61K38/00;C07K14/47;C07K16/18;G01N33/68;(IPC1-7):C07K1/00;A61K35/14;A01N37/18;A01N43/04;G01N33/53;C07H21/02 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|