| 摘要 |
<p>The invention concerns a method for preparing 2-thienyl-ethylamine derivatives of general formula (I) and their acid additive salts, in which R represents a halogen atom and R1 represents a C1-C4 alkyl group, characterised in that it consists in reacting a thienyglycidic acid derivative of general formula (II) in which M represents an alkaline metal atom or an alkaline-earth metal fraction, with a phenylglycine ester, optionally in the form of a strong acid salt, of general formula (III) in which R and R1 have the same meaning as above, in the presence of an alkaline metal borohydride of general formula (IV): X-Y in which X represents an alkaline metal atom and Y represents a group of general formula (a): -BH3CN or (b): BH(4-w)Zw in which Z represents a carboxylic acid radical and optionally in the presence of a C1-C4 carboxylic acid, which results in the required compound in the form of a free base which can be treated if necessary, with an acid to obtain the additive salt of this compound.</p> |
