发明名称 |
ANTI-MITOTIC AGENTS WHICH INHIBIT TUBULIN POLYMERIZATION |
摘要 |
Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo¢b!thiophenes and benzo¢b!thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described. Additional aspects described here are certain diaryl ether benzo¢b!thiophene derivatives. Also described are particular analogs derived from dihydronaphthalene which have proven particularly effective. Certain new benzofuran analogs are described, as well as certain sulfur oxide benzo¢b!thiophene analogs. Important compounds described herein include the first nitrogen-containing derivatives of combretastatin. These include nitro, amino and azide combretastatin derivatives.
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申请公布号 |
CA2283471(A1) |
申请公布日期 |
1998.09.11 |
申请号 |
CA19982283471 |
申请日期 |
1998.03.06 |
申请人 |
BAYLOR UNIVERSITY;ARIZONA DISEASE CONTROL RESEARCH COMMISSION |
发明人 |
SHIRALI, ANUPAMA;MOCHARLA, VANI P.;PINNEY, KEVIN G.;PETTIT, GEORGE R.;DEL PILAR MAJIA, MARIA |
分类号 |
A61K31/381;A61P35/00;A61P43/00;C07C43/23;C07C49/84;C07C205/37;C07D307/80;C07D333/50;C07D333/56;C07D333/64;(IPC1-7):C07D333/64;C07C49/115;C07C43/205 |
主分类号 |
A61K31/381 |
代理机构 |
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