发明名称 |
POLYSACCHARIDE-PEPTIDE-CONJUGATES |
摘要 |
The invention relates to a polysaccharide-peptide conjugate wherein the polysaccharide is advantageously immunogenic, which comprises a polysaccharide chain composed of repeat units and a plurality of peptide moieties, each moiety containing a cysteine residue and being covalently attached at random along the polysaccharide chain, through an indirect bond being achieved through either a linker or a spacer-linker moiety provided that the spacer entity of the spacer-linker moiety is linked to the amino, hydroxyl or carboxyl group of the polysaccharide. To this end a useful linker may be, e.g., N-(gamma-maleimidobutyrloxy)succinimide ester. Such a conjugate may typically exhibit a "Rake" configuration. Conjugation processes are also disclosed. Conjugates of the invention are in particular useful in the vaccinal field to elicit a protective long term immune response against a pathogenic microorganism from which the Immunogenic polysaccharide is derived. |
申请公布号 |
WO9831393(A3) |
申请公布日期 |
1998.09.11 |
申请号 |
WO1998EP00654 |
申请日期 |
1998.01.21 |
申请人 |
PASTEUR MERIEUX SERUMS & VACCINS;MOREAU, MONIQUE;MISTRETTA, NOELLE |
发明人 |
MOREAU, MONIQUE;MISTRETTA, NOELLE |
分类号 |
A61K39/385;A61K31/00;A61K47/48;A61P37/00;A61P37/02;C07K14/00 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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