发明名称 |
IMMUNOTOXINS AND METHODS OF INDUCING IMMUNE TOLERANCE |
摘要 |
Provided are novel DT- and ETA-based immunotoxins and a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease. Also provided is a method of inhibiting a rejection response by inducing immune tolerance in a recipient to a foreign mammalian donor tissue or cells, comprising the steps of: a) exposing the recipient to an immunotoxin so as to reduce the recipients' peripheral blood T-cell lymphocyte population by at least 80%, wherein the immunotoxin is anti-CD3 antibody linked to a diphtheria protein toxin, wherein the protein has a binding site mutation; and b) transplanting the donor cells into the recipient, whereby a rejection response by the recipient to the donor organ cell is inhibited, and the host is tolerized to the donor cell.
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申请公布号 |
CA2284079(A1) |
申请公布日期 |
1998.09.11 |
申请号 |
CA19982284079 |
申请日期 |
1998.03.05 |
申请人 |
UNIVERSITY OF ALABAMA RESEARCH FOUNDATION;THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MA, SHENGLIN;NEVILLE, DAVID M.;THOMAS, JUDITH M.;HU, HUAIZHONG;KNECHTLE, STUART J.;THOMPSON, JERRY T. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K47/48;A61P37/06;C07K14/195;C07K14/21;C07K14/34;C07K16/28;C07K19/00;(IPC1-7):C07K19/00;A61K31/16;A61K35/28;A61K31/365;A61K31/57 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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