发明名称 |
Oviductal catalase binding to the membranes of spermatozoa and uses thereof |
摘要 |
The present invention relates to a novel oviductal catalase having a molecular weight of about 60 KDa and which binds to a spermatozoa membrane outer surface, wherein said catalase once bound to the spermatozoa membrane outer surface protects said spermatozoa against oxidation. A method of stabilizing spermatozoa membrane and improving spermatozoa survival during migration in oviduct and/or uterus for artificial insemination; which comprises coating spermatozoa with such a catalase enzyme. A method of improving spermatozoa survival during migration in oviduct and/or uterus in cases of female infertility due to the absence of endogenous catalase in the genital tract of the female subject; which comprises administering catalase in the female genital tract before co+E,uml i+EE t or coating spermatozoa with a catalase enzyme for artificial insemination. Also provided herein are method of diagnostic of male or female infertility. |
申请公布号 |
AU6201598(A) |
申请公布日期 |
1998.09.09 |
申请号 |
AU19980062015 |
申请日期 |
1998.02.18 |
申请人 |
UNIVERSITE LAVAL |
发明人 |
SERGE LAPOINTE;MARC-ANDRE SIRARD |
分类号 |
A01N1/02;A61K38/00;A61K38/44;C12N5/076;C12N9/08;C12Q1/30;G01N33/573 |
主分类号 |
A01N1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|