| 摘要 |
Described herein are D4 receptor-selective compounds of general formula (I), wherein R<1> is a 5- or 6-membered aromatic or heteroaromatic ring, attached at the meta- or para-position of the benzamide phenyl group, wherein said ring is optionally substituted with 1 or 2 groups independently selected from loweralkyl, loweralkoxy, hydroxy, halo, cyano, loweralkyl-S-, loweralkyl-SO-, loweralkyl-SO2-, (loweralkyl)2NSO2-, H(O)C-, HO2C-, trifluoromethyl, trifluoromethoxy, H2N-, loweralkyl-NH- and (loweralkyl)2N-, loweralkylcarbonyl; R<2> is selected from an optionally substituted 5- or 6-membered aromatic or heteroaromatic ring, and an optionally substituted 6-membered aromatic or heteroaromatic ring fused to a 5- or 6-membered hetero- or carbocycle; n is 1 or 2; and salts, solvates, stereoisomers or hydrates thereof. Also described is the use of these compounds as pharmaceuticals to treat indications for which a dopamine D4 receptor antagonist is implicated, such as schizophrenia and anxiety. |
