发明名称 |
INCLUSION COMPLEXES OF 3-MORPHOLINO-SYDNONIMINE OR ITS SALTS OR ITS TAUTOMER ISOMER, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
<p>PCT No. PCT/HU91/00013 Sec. 371 Date Jan. 2, 1992 Sec. 102(e) Date Jan. 2, 1992 PCT Filed Mar. 28, 1991.The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared by a) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, or b) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.</p> |
申请公布号 |
EP0478732(B1) |
申请公布日期 |
1998.09.09 |
申请号 |
EP19910907217 |
申请日期 |
1991.03.28 |
申请人 |
THERABEL INDUSTRIES S.A. |
发明人 |
VIKMON, MARIA;SZEJTLI, JOZSEF;SZENTE, LAJOS;GAAL, JOZSEF;HERMECZ, ISTVAN;HORVATH, AGNES;MARMAROSI, KATALIN;HORVATH, GABOR;MUNKACSI, IREN |
分类号 |
A61K31/41;A61K31/4245;A61K31/535;A61K31/5375;A61K47/40;A61K47/48;A61P9/08;A61P9/10;C07D265/28;C07D271/04;C07D295/30;C08B37/00;C08B37/06;C08B37/16;(IPC1-7):C07D271/04 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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