| 发明名称 |
High level of expression of ingap in bacterial and euraryotic cells |
| 摘要 |
Removal of the nucleotide sequence encoding the signal peptide from the INGAP coding sequence allows cultured cells to express substantial amounts of INGAP activity. Previous attempts have provided only low yields of INGAP, possibly because the signal sequence of INGAP is toxic to the cells.
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| 申请公布号 |
US5804421(A) |
申请公布日期 |
1998.09.08 |
| 申请号 |
US19970909725 |
申请日期 |
1997.08.12 |
| 申请人 |
EASTERN VIRGINIA MEDICAL SCHOOL OF THE MEDICAL COLLEGE FO HAMPTON ROADS |
发明人 |
VINIK, AARON I.;PITTENGER, GARY L.;RAFAELOFF-PHAIL, RONIT;BARLOW, SCOTT W. |
| 分类号 |
C12N15/09;C07K1/22;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;(IPC1-7):C12N15/00 |
主分类号 |
C12N15/09 |
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