发明名称 |
Inhibition of gene transcription by polyamide dna-binding ligands |
摘要 |
The invention provides polyamides suitable for modulating cellular or viral gene expression by binding to an identified target DNA sequence adjacent to the binding site of a minor groove transcription factor protein. The polyamides of the present invention are useful for the treatment of a human infected with a virus such as HIV-1. The polyamides of the present invention are also useful for the treatment of conditions, such as cancers, that result from the expression or over-expression of cellular genes, particularly oncogenes. |
申请公布号 |
AU6151798(A) |
申请公布日期 |
1998.09.08 |
申请号 |
AU19980061517 |
申请日期 |
1998.02.11 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
JOEL M GOTTESFELD;PETER B. DERVAN;DONALD E. MOSIER;ELDON E. BAIRD |
分类号 |
C12N15/09;A61K31/4178;A61K31/787;A61K38/00;A61K47/48;A61P31/04;A61P31/10;A61P31/12;A61P31/18;A61P35/00;C07D403/14 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|