ACID ADDUCT SALT OF OPTICALLY ACTIVE PIPERDINE DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain the subject compound having an excellent stability suitable as a medicine by forming a salt of a specific derivative with benzene sulfonic acid, etc. SOLUTION: This acid adduct salt of an optically active piperidine derivative is an objective salt expressed by the formula and having an absoluyte configuration of (S) compound, preferably (S)-4- 4-[(4-chlorophenyl)(2-pyridyl) methoxy]piperidino}butanoic acid.benzene sulfonic acid salt. Further, in order to obtain the above salt, it is preferable to form the salt by using 0.8-2.5 fold mol of benzene sulfonic acid or benzoic acid based on 1mol of (S)-piperidine derivative expressed by the formula in a solvent such as ethanol a 5-50 deg.C reaction temperature.