Compounds for use in adept

摘要

Compounds of Formula (I) wherein A is optionally substituted phenyl or naphthyl; X is a direct bond, CH2 or oxygen; V is NH or O; r is 0-2, provided that when V is O then r is zero; Y<1> and Y<2> are independently selected from chloro, bromo, iodo, -O-SO2-C1-4alkyl and -O-SO2-phenyl; W is COOH or 1H-1,2,3,4-tetrazol-5-yl; R<1> is hydrogen, fluoro, chloro, bromo, C1-4alkyl or C1-4alkoxy; p is 0-4 wherein values of R<1> may be the same or different and when p is less than 4 remaining substituent values are hydrogen; R<2> is C1-6alkyl, hydroxyC1-6alkyl, phenylC1-6alkyl, C1-4alkoxyC1-4alkyl, phenylC1-4alkoxyC1-4alkyl, C1-4alkylthioC1-4alkyl, phenylC1-4alkylthioC1-4alkyl or carbamoylC1-4alkyl; or an enantiomer, diastereoisomer, pharmaceutically acceptable salt, in-vivo hydrolysable ester or solvate thereof. These compounds are useful for cancer treatment using antibody directed enzyme prodrug therapy (ADEPT), particularly as carboxypeptidase B activatable prodrugs.