| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound producible from a specific fungus isolated from soil, and having cell cycle-inhibiting activity and antitumor activity. SOLUTION: This new compound, RKS-1778 expressed by the formula, is obtained by culturing a filamentous fungus SNF-1778 strain belonging to Phoma isolated from soil at Matumoto city in Nagano prefecture, and isolating and collecting from the culture mixture. RKS-1778 can be used as active components of a cell cycle inhibitor and an antitumor agent, and an effective daily dose is preferably about 0.1mg to 1g for an adult. Further, MKS-1778 is useful as a biochemical testing reagent, and it can suppress the progresses of cell cycles in the M-stage to suppress the growth of cells when administered directly to various kinds of cell-culturing systems as a solution in an organic solvent, etc. For example, the range of an effective use for suppressing the growth of a cancer cell using RKS-1778 as an active component is preferably 1×10<-7> to 1×10<-5> g/ml. |
