发明名称 |
Peptide and peptide analog protease inhibitors |
摘要 |
Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae I and II: <IMAGE> I <IMAGE> II in which R1 is preferably 2-methyl propene, 2-butene, cyclohexyl or cyclohexylmethyl; R2, R4, and R8 are each independently methyl or ethyl; R3 is preferably iso-butyl or phenyl; R5 is preferably iso-butyl; R6 is H or methyl; R7-(Q)n is preferably benzyloxycarbonyl or acetyl; Q is preferably -C(O)-; RB is preferbly iso-butyl; RA=-(T)m-(D)m-R1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C3-4 alkenyl being more preferred; and X is preferably an alpha -ketoester or alpha -ketoamide or aldehyde.
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申请公布号 |
US5804560(A) |
申请公布日期 |
1998.09.08 |
申请号 |
US19950369422 |
申请日期 |
1995.01.06 |
申请人 |
SIBIA NEUROSCIENCES, INC. |
发明人 |
MCDONALD, IAN ALEXANDER;ALBRECHT, ELISABETH;MUNOZ, BENITO |
分类号 |
A61K38/00;A61K31/00;A61P25/00;A61P25/16;A61P25/28;C07C237/22;C07K5/02;C07K5/06;C07K5/065;C07K5/078;C07K5/08;C07K5/083;(IPC1-7):A61K38/05 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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