| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain a new compound, having two actions of inhibiting actions on a lipoxygenase and inhibiting actions on a thromboxane synthase and useful for treating and mitigating allergic diseases, etc. SOLUTION: This compound is represented by formula I (one of R1 to R3 is 3-pyridyl, etc., and the others are H, a 1-8C alkyl, etc.; R4 is H or a lower alkyl; R5 is H, a lower alkyl, etc.; A is a bond, a 1-20C alkylene, etc.), e.g. N-hydroxyl-N-[12[1-[2-(3-pyridyl)indolyl]]dodecyl]urea. The compound represented by formula I is obtained by reacting an alcohol represented by formula II (Q is represented by formula III) with N,O-bis(tert-butoxycarbonyl) hydroxylamine under conditions of the Mitsunobu reaction, providing a compound represented by formula IV (P is a protecting group), then hydrolyzing the resultant compound with an acid, affording a compound represented by formula V and further reacting the compound represented by formula V with trimethylsilyl isocyanate.</p> |
