| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound consisting of a specific sulfonamide-substituted chromane, exhibiting K<+> channel blocking and gastric- acid secretion inhibiting effects, and useful for, e.g. prevention or treatment of gastric ulcer, enterelcosis, esophagitis regurgitica, diarrhea, allorhythmia and ventricular fibrillation. SOLUTION: This compound is a new chromane derivative shown by formula I R(1) and R(2) are each H, CF3 , C2 F5 , a 1-6C alkyl, (substituted)phenyl or the like; R(A) is O, H, a 1-6C alkanoyloxyl or the like; R(B) is H, forms a bond together with R(A) or the like; R(3) is shown by formula II (R(9) is H or a 3-8C cycloalkyl; (n) is 0 to 10; (m) is 0 or 1; R(11) is H, a 1-6C alkyl or the like; R(4) is an R(12)-Cr H2r [R(12) is H, a 3-8C cycloalkyl, piperidyl, 1- pyrrolidyl or the like]; R(5) to R(8) are each H, a halogen, a 1-6C alkyl, a 3-8C cycloalkyl, CN, CF3 , N3 or the like}, and useful, e.g. as a K<+> channel blocking agent, gastric-acid secretion inhibitor, and for treatment of duodenal ulcer, esophagitis regurgitica, diarrhea, for prevention of treatment of allorhythmia and for prevention of ventricular fibrillation.
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