| 摘要 |
<p>In the procedure for the production of a formulation of parenterally administrable pharmaceutical preparations, a liposome dispersion is used as a carrier for a pharmaceutical active compound. For the preparation of the liposome dispersion, an aqueous predispersion of one or more amphiphilic substances is fed to a high-pressure homogenizer in which the predispersion is pumped under a pressure from 600 bar to 900 bar through a homogenizer nozzle (2) having a diameter of 0.1 to 0.5 mm. The homogenizer nozzle has an inlet channel (14, 16) and an outlet channel (15, 18) and consists of a hard ceramic plate (11), in which the bore (13) is present, pressed into a steel body (12, 19). The inlet channel (14, 16) and the outlet channel (15, 18) are likewise incorporated into the steel body (12, 19).</p> |
